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KMID : 0613820110210010062
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Journal of Life Science
2011 Volume.21 No. 1 p.62 ~ p.67
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Antioxidant Activity and Alpha-Glucosidase Inhibitory Activity of Stings of Gleditsia sinensis Extracts
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Lee Jung-Min
Park Jae-Hee
Chu Won-Mi
Yoon Yi-Mook
Park Eun-Ju
Park Hae-Ryong
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Abstract
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This study was performed to investigate the physiological activities of stings of Gleditsia sinensis extracts. Antioxidant activity was evaluated by measuring total phenolic contents (TPC), comet assay, and 2.2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA). Anti-diabetic activity was measured by inhibition activities on α-glucosidase. Stings of Gleditsia sinensis extracts were prepared by extracting them with methanol and ethanol. The methanolic extracts showed the highest phenol content (1.12 g/100 g gallic acid equivalents). The α-glucosidase inhibitory activity of methanol extracts were 17.9% higher, and that of ethanol extracts were 10.3% higher at a concentration of 1 ㎎/ml. These results indicate that stings of Gleditsia sinensis might be potential candidates as antioxidant and anti-diabetic agents.
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KEYWORD
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Stings of Gleditsia sinensis, antioxidant, α-glucosidase, anti-diabetes
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